Vesicular Formation of Trans-Ferulic Acid: an Efficient Approach to Improve the Radical Scavenging and Antimicrobial Properties

Abstract Purposes Reactive oxygen species production is harmful to human’s health. The presence of antioxidants in the body may help diminish reactive species. Trans -ferulic acid a good antioxidant, but its low water solubility excludes utilization. study aims explore whether vesicular drug delivery could be way overcome poor absorption trans hence improving antimicrobial efficiency and antioxidant effect. Methods Niosomal vesicles containing were prepared by film hydration method. obtained investigated terms morphology, size, entrapment efficiency, release behavior, cellular cytotoxicity, protection study, evaluations. Results optimized niosomal formulation had particle size 158.7 nm 21.64%. results showed that 25 μM enhance viability human foreskin fibroblast HFF cell line against production. minimum effective dose plain Staphylococcus aurous (ATCC 29213) was 750 µg/mL 375 µg/mL, respectively, for Escherichia coli 25922), it 187/5 respectively. also improve bactericidal concentration , Acinobacter baumannii 19606). Conclusion These revealed an improvement both antibacterial effects formulation.